Life-event specificity: bipolar disorder compared with unipolar depression

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Life-event specificity: bipolar disorder compared with unipolar depression.

BACKGROUND Little is known about the impact of different types of stressful events (for example divorce v. bereavement) on unipolar depression compared with bipolar disorder. Inconsistencies exist concerning the association between independent events (beyond an individual's control, such as bereavement) and bipolar disorder. AIMS To examine the role of specific, independent and dependent even...

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BACKGROUND Analysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding. METHODS We computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted mag...

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Bipolar and unipolar depression.

Since Kraepelin grouped affective disorders under the title of 'manic-depressive insanity', there has been controversy over whether the bipolar and unipolar entities within this are distinct affective disorders or whether they are merely two ends of an affective continuum. In order to bring some clarity and goal-posts to this argument, we define the criteria that must be fulfilled by diseases i...

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More severe impairment of manual dexterity in bipolar disorder compared to unipolar major depression.

BACKGROUND Mood disorders are associated with various neurocognitive deficits. However, few studies have reported the impairment of motor dexterity in unipolar depression and bipolar disorder. In the present study, manual dexterity was compared between unipolar major depression, bipolar disorder, and healthy controls. METHODS Manual dexterity was assessed by the Purdue pegboard test in 98 pat...

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ژورنال

عنوان ژورنال: British Journal of Psychiatry

سال: 2012

ISSN: 0007-1250,1472-1465

DOI: 10.1192/bjp.bp.112.111047